|
|
17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP+ <=> 17alpha-hydroxyprogesterone + NADPH + H+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
|
K
|
|
BRENDA:
BR29214;
BS188323
KEGG:
R03325
MetaCyc:
1.1.1.149-RXN
SABIO-RK:
3135
|
|
|
|
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD+ <=> 17alpha-hydroxyprogesterone + NADH + H+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
|
|
BRENDA:
BR29214-a
MetaCyc:
1.1.1.149-RXN_WOP
SABIO-RK:
3134
|
|
|
|
17alpha-hydroxyprogesterone + NADPH + O2 <=> 4-androstene-3,17-dione + acetate + NADP+ + H2O
|
1.14.13.54
ketosteroid monooxygenase
|
–
|
|
|
BRENDA:
BR49817
KEGG:
R08206
MetaCyc:
RXN-7819
|
|
|
|
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 4-androstene-3,17-dione + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
BK
|
|
BRENDA:
BR362
KEGG:
R08518
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 17alpha-hydroxyprogesterone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
K
|
|
BRENDA:
BS258003
KEGG:
R02211
|
|
|
|
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 11-deoxycortisol + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
K
|
|
BRENDA:
BS427270
KEGG:
R03326
|
|
|
|
17alpha-hydroxypregnenolone + NAD+ <=> 17alpha-hydroxyprogesterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
K
|
|
KEGG:
R03327
|
|
|
|
17alpha-hydroxyprogesterone + 2 reduced_ferredoxin + O2 + 2 H+ <=> 21-deoxycortisol + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
K
|
|
KEGG:
R03329
|
|
|
|
17alpha-hydroxyprogesterone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 4-androstene-3,17-dione + acetate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
MetaCyc:
4.1.2.30-RXN
|
|
|
|
pregn-5-ene-3,20-dione-17-ol <=> 17alpha-hydroxyprogesterone
|
5.3.3.1
steroid Delta-isomerase
|
–
|
M
|
|
MetaCyc:
RXN66-351
|
|
|
|
progesterone + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 17alpha-hydroxyprogesterone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN66-355
|
|
|
|
17alpha-hydroxyprogesterone + reduced_adrenodoxin + O2 + H+ <=> 11-deoxycortisol + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN66-356
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS427512
|
|
|
|
17alpha-hydroxyprogesterone + [reduced_NADPH-P450_reductase] + O2 <=> 11-deoxycortisol + [oxidized_NADPH-P450_reductase] + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS427271
|
|
|
|
17alpha-hydroxyprogesterone + reduced_acceptor + O2 <=> dehydroepiandrosterone + 4-androstene-3,17-dione + A + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS416054
|
|
|
|
17alpha-hydroxyprogesterone + reduced_acceptor + O2 <=> 11alpha,17alpha-dihydroxyprogesterone + A + H2O
|
1.14.99.14
progesterone 11alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS442139
|
|
|
|
17alpha-hydroxyprogesterone + reduced_acceptor + O2 <=> 11-deoxycortisol + A + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS403311
|
|
|
|
2 progesterone + 2 reduced_acceptor + 2 O2 <=> 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + 2 A + 2 H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS394960
|
|
|
|
progesterone + reduced_acceptor + O2 <=> 17alpha-hydroxyprogesterone + A + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
|
|
BRENDA:
BS394961
|
|
|
|
17alpha-hydroxyprogesterone + NADH + O2 <=> 11-deoxycortisol + NAD+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186797
|
|
|
|
17alpha-hydroxypregnenolone + NADH + H+ <=> 17alpha-hydroxyprogesterone + NAD+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS425314
|
|
|
|
17alpha-hydroxyprogesterone + NADPH <=> 17alpha,20beta-dihydroxy-4-pregnene-3-one
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS188325
|
|
|
|
17alpha-hydroxyprogesterone + NADPH <=> 17alpha,20beta-dihydroxy-4-pregnen-3-one
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS371551
|
|
|
|
17alpha-hydroxyprogesterone + NADPH + O2 <=> 11-deoxycortisol + NADP+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186803
|
|
|
|
17alpha-hydroxyprogesterone + NADPH <=> 5alpha-pregnan-17alpha-ol-3,20-dione + NADP+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS260957
|
|
|
|
17alpha-hydroxyprogesterone + NADPH + O2 <=> corticosteroids + NADP+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS369932
|
|
|
|
17alpha,20beta-Dihydroxypregn-4-ene-3-one + NADP+ <=> 17alpha-hydroxyprogesterone + NADPH
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS188344
|
|
|
|
17alpha-hydroxyprogesterone + NADPH <=> 3beta,17-dihydroxy-4-pregnen-20-one + NADP+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS257054
|
|
|
|
progesterone + reduced_acceptor + O2 <=> 17alpha-hydroxyprogesterone + acceptor + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
|
|
BRENDA:
BS415732
|
|
|
|
17alpha-hydroxyprogesterone + acceptor <=> 1,4-pregnene-17alpha-ol-3,20-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS258849
|
|
|
|
17alpha-hydroxy-pregn-5-en-3,20-dione <=> 17alpha-hydroxyprogesterone
|
5.3.3.1
steroid Delta-isomerase
|
–
|
|
|
BRENDA:
BS423963
|
|
|
|
17alpha-hydroxyprogesterone + reduced_megaredoxin + O2 <=> (15beta,17alpha)-15,17-dihydroxyprogesterone + oxidized_megaredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS403314
|
|
|
|
NADPH + 17alpha-hydroxyprogesterone <=> 4-androstene-3,17-dione + NADP+
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
SABIO-RK:
7635
|
|
|
|
progesterone + NADPH + O2 <=> 17alpha-hydroxyprogesterone + NADP+ + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.25
cholesterol 24-hydroxylase
|
–
–
|
|
|
SABIO-RK:
7671
|
|